Abstract
Motivation
Understanding RNA folding at the level of secondary structures can give important insights concerning the function of a molecule. We are interested to learn how secondary structures change dynamically during transcription, as well as whether particular secondary structures form already during or only after transcription. While different approaches exist to simulate cotranscriptional folding, the current strategies for visualization are lagging behind. New, more suitable approaches are necessary to help with exploring the generated data from cotranscriptional folding simulations.
Results
We present DrForna, an interactive app for visualizing the time course of a cotranscriptional RNA folding simulation using a treemap. Specifically, users can scroll along the time axis and see the population of structures that are present at any particular time point.
Understanding RNA folding at the level of secondary structures can give important insights concerning the function of a molecule. We are interested to learn how secondary structures change dynamically during transcription, as well as whether particular secondary structures form already during or only after transcription. While different approaches exist to simulate cotranscriptional folding, the current strategies for visualization are lagging behind. New, more suitable approaches are necessary to help with exploring the generated data from cotranscriptional folding simulations.
Results
We present DrForna, an interactive app for visualizing the time course of a cotranscriptional RNA folding simulation using a treemap. Specifically, users can scroll along the time axis and see the population of structures that are present at any particular time point.
| Originalsprache | Englisch |
|---|---|
| Fachzeitschrift | Bioinformatics |
| Jahrgang | 39 |
| Ausgabenummer | 9 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - Sept. 2023 |